Nicolas Dumont, PT, Ph.D.

–
Nicolas Dumont

Associate professor

Contact details (Research)
Sainte-Justine Hospital research center
3175 Ch. de la côte Sainte-Catherine
Room 4715
Montreal (Quebec) H3T 1C5
T (514) 345-4931 ext. 3263

Contact details (School of Rehabilitation)
T 514 343-6111 ext. 7494
F 514 343-6929
nicolas.dumont.1@umontreal.ca

Program
physiotherapy

Education

  • B.Sc. Physiotherapy, University Laval (2005)
  • M.Sc. Physiology-endocrinology, CHUQ research center, University Laval (2007)
  • Ph.D. Physiology-endocrinology, CHUQ research center, University Laval (2013)
  • Post-doctoral fellow in regenerative medicine, Ottawa Hospital Research Institute, University of Ottawa (2013-2016)

Current research projects

  • The role of acute and chronic inflammation on skeletal muscle regeneration
  • The effect of pro-resolving mediators of inflammation on muscle healing.
  • Effect of various myopathies on muscle stem cell behaviour during muscle regeneration.

Selected publications

  • Dumont NA, Wang YX, Von Maltzahn J, Pasut A, Bentzinger CF, Brun CE, Rudnicki MA. Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division. Nature Med. 2015 Dec;21(12):1455-63.
  • Dufresne SS*, Dumont NA* (*co-first author), Boulanger-Piette A, Fajardo VA, Gamu D, Kake-Guena SA, David RO, Bouchard P, Lavergne E, Penninger JM, Pape PC, Tupling AR, Frenette J. Muscle RANK is a key regulator of calcium storage, SERCA activity, and function of fast-twitch skeletal muscles. AJP – Cell Physiol. 2016 Apr 15;310(8):C663-72.
  • Dick SA, Chang NC, Dumont NA, Bell R, Putinski C, Kawabe Y, Litchfield DW, Rudnicki MA, Megeney LA. Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. PNAS. 2015 Sep 22 :112(38) :E5246-52
  • Dumont NA, Wang YX, Rudnicki MA. Intrinsic mechanisms regulating satellite cell function. Development. 2015 May 1;142(9):1572-81.
  • Dufresne SS*, Dumont NA* (*co-first author), Bouchard P, Lavergne E, Penninger JM, Frenette J. Osteoprotegerin protects against muscular dystrophy. Am J Pathol. 2015 Apr;185(4):920-6.
  • Price FD, von Maltzahn J, Bentzinger CF, Dumont NA, Yin H, Chang NC, Wilson DH, Frenette J, Rudnicki MA. Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nature Med. 2014 Oct;20(10):1174-81.
  • Dumont NA, Frenette J. Macrophage colony-stimulating factor-induced macrophage differentiation promotes regrowth in atrophied skeletal muscles and C2C12 myotubes. Am J Pathol. 2013 Feb;182(2):505-15.

Research interests

  • To develop pro-resolving mediators (compounds that dampen the inflammatory reaction to avoid chronicity, in opposition to anti-inflammatory drugs that completely block the inflammatory reaction) for the treatment of acute and chronic muscle injuries.
  • To understand the defects in muscle regeneration observed in muscle pathologies such as Duchenne muscular dystrophy.
  • To analyze muscle function and the effects of different treatments in patients suffering of muscle atrophy caused by a related condition (ex: cancers, chronic cardiac or pulmonary diseases, ageing).