Nicolas Dumont, Ph.D.

Assistant professor

Contact details (Research)
Sainte-Justine Hospital research center
3175 Ch. de la côte Sainte-Catherine
Montréal (Québec) H3T 1C5
Room 5.17.007
T (514) 345-4931 ext. 7876

Contact details (School of Rehabilitation)
T
514 343-6111 ext. 7494
nicolas.dumont.1@umontreal.ca

Program
Physiotherapy


Education

  • B.Sc. Physiotherapy, University Laval (2005)
  • M.Sc. Physiology-endocrinology, CHUQ research center, University Laval (2007)
  • Ph.D. Physiology-endocrinology, CHUQ research center, University Laval (2013)
  • Post-doctoral fellow in regenerative medicine, Ottawa Hospital Research Institute, University of Ottawa (2013-2016)

Current research projects

  • The role of acute and chronic inflammation on skeletal muscle regeneration
  • The effect of pro-resolving mediators of inflammation for the treatment of muscle injuries and diseases
  • Muscle stem cell dysfunction in muscle diseases
  • Functional characterisation of novel rare myopathies

Selected publications

  • Duchesne, E., Dufresne, S. S., & Dumont, N. A. (2017). Impact of Inflammation and Anti-inflammatory Modalities on Skeletal Muscle Healing: From Fundamental Research to the Clinic. Physical Therapy, 97(8), 807-817. doi:10.1093/ptj/pzx056
  • Dumont, N. A., Wang, Y. X., von Maltzahn, J., Pasut, A., Bentzinger, C. F., Brun, C. E., & Rudnicki, M. A. (2015). Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division. Nature Medicine, 21(12), 1455-1463. doi:10.1038/nm.3990
  • Dufresne, S. S., Dumont, N. A., Boulanger-Piette, A., Fajardo, V. A., Gamu, D., Kake-Guena, S. A., . . . Frenette, J. (2016). Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles. American Journal of Physiology. Cell Physiology, 310(8), C663-672. doi:10.1152/ajpcell.00285.2015
  • Dick, S. A., Chang, N. C., Dumont, N. A., Bell, R. A., Putinski, C., Kawabe, Y., . . . Megeney, L. A. (2015). Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. Proceedings of the National Academy Sciences of the United States of America, 112(38), E5246-5252. doi:10.1073/pnas.1512869112
  • Dumont, N. A., Wang, Y. X., & Rudnicki, M. A. (2015). Intrinsic and extrinsic mechanisms regulating satellite cell function. Development, 142(9), 1572-1581. doi:10.1242/dev.114223
  • Dufresne, S. S., Dumont, N. A., Bouchard, P., Lavergne, E., Penninger, J. M., & Frenette, J. (2015). Osteoprotegerin protects against muscular dystrophy. American Journal of Pathology, 185(4), 920-926. doi:10.1016/j.ajpath.2015.01.006
  • Price, F. D., von Maltzahn, J., Bentzinger, C. F., Dumont, N. A., Yin, H., Chang, N. C., . . . Rudnicki, M. A. (2014). Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nature Medicine, 20(10), 1174-1181. doi:10.1038/nm.3655
  • Dumont, N. A., & Frenette, J. (2013). Macrophage colony-stimulating factor-induced macrophage differentiation promotes regrowth in atrophied skeletal muscles and C2C12 myotubes. American Journal of Pathology, 182(2), 505-515. doi:10.1016/j.ajpath.2012.10.010

Research interests

  • Musculoskeletal regeneration
  • Acute and chronic inflammation
  • Atrophied muscle function
  • Muscle dystrophies
  • Tendinopathies