Nicolas Dumont, Ph.D.

Education

• B.Sc. Physiotherapy, University Laval (2005)
• M.Sc. Physiology-endocrinology, CHUQ research center, University Laval (2007)
• Ph.D. Physiology-endocrinology, CHUQ research center, University Laval (2013)
• Post-doctoral fellow in regenerative medicine, Ottawa Hospital Research Institute, University of Ottawa (2013-2016)

Current research projects

• The role of acute and chronic inflammation on skeletal muscle regeneration
• The effect of pro-resolving mediators of inflammation for the treatment of muscle injuries and diseases
• Muscle stem cell dysfunction in muscle diseases
• Functional characterisation of novel rare myopathies

Selected publications

• Feichtinger, R. G., Mucha, B. E., Hengel, H., Orfi, Z., Makowski, C., Dort, J., . . . Dumont, N. A. (2019). Biallelic variants in the transcription factor PAX7 are a new genetic cause of myopathy. Genetics in Medicine, 21(11), 2521-2531. doi:10.1038/s41436-019-0532-z
• Duchesne, E., Dufresne, S. S., & Dumont, N. A. (2017). Impact of Inflammation and Anti-inflammatory Modalities on Skeletal Muscle Healing: From Fundamental Research to the Clinic. Physical Therapy, 97(8), 807-817. doi:10.1093/ptj/pzx056
• Dumont, N. A., Wang, Y. X., von Maltzahn, J., Pasut, A., Bentzinger, C. F., Brun, C. E., & Rudnicki, M. A. (2015). Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division. Nature Medicine, 21(12), 1455-1463. doi:10.1038/nm.3990
• Dufresne, S. S., Dumont, N. A., Boulanger-Piette, A., Fajardo, V. A., Gamu, D., Kake-Guena, S. A., . . . Frenette, J. (2016). Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles. American Journal of Physiology. Cell Physiology, 310(8), C663-672. doi:10.1152/ajpcell.00285.2015
• Dick, S. A., Chang, N. C., Dumont, N. A., Bell, R. A., Putinski, C., Kawabe, Y., . . . Megeney, L. A. (2015). Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. Proceedings of the National Academy Sciences of the United States of America, 112(38), E5246-5252. doi:10.1073/pnas.1512869112
• Dumont, N. A., Wang, Y. X., & Rudnicki, M. A. (2015). Intrinsic and extrinsic mechanisms regulating satellite cell function. Development, 142(9), 1572-1581. doi:10.1242/dev.114223
• Dufresne, S. S., Dumont, N. A., Bouchard, P., Lavergne, E., Penninger, J. M., & Frenette, J. (2015). Osteoprotegerin protects against muscular dystrophy. American Journal of Pathology, 185(4), 920-926. doi:10.1016/j.ajpath.2015.01.006
• Price, F. D., von Maltzahn, J., Bentzinger, C. F., Dumont, N. A., Yin, H., Chang, N. C., . . . Rudnicki, M. A. (2014). Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nature Medicine, 20(10), 1174-1181. doi:10.1038/nm.3655
• Dumont, N. A., & Frenette, J. (2013). Macrophage colony-stimulating factor-induced macrophage differentiation promotes regrowth in atrophied skeletal muscles and C2C12 myotubes. American Journal of Pathology, 182(2), 505-515. doi:10.1016/j.ajpath.2012.10.010

Research interests

• Musculoskeletal regeneration
• Acute and chronic inflammation
• Atrophied muscle function
• Muscle dystrophies
• Tendinopathies