{"id":13858,"date":"2017-11-09T22:36:54","date_gmt":"2017-11-09T21:36:54","guid":{"rendered":"https:\/\/readaptation.umontreal.ca\/?page_id=13858\/"},"modified":"2022-07-11T17:42:05","modified_gmt":"2022-07-11T16:42:05","slug":"nicolas-dumont-pt-ph-d","status":"publish","type":"page","link":"https:\/\/readaptation.umontreal.ca\/en\/research\/researchers\/nicolas-dumont-pt-ph-d\/","title":{"rendered":"Nicolas Dumont, Ph.D."},"content":{"rendered":"
\n

–<\/span><\/p>\n

\"Nicolas<\/p>\n<\/div>\n

\n

Associate professor<\/h3>\n

Contact details (Research)
\n<\/strong>Sainte-Justine Hospital research center
\n3175 Ch. de la c\u00f4te Sainte-Catherine
\nMontr\u00e9al (Qu\u00e9bec) H3T 1C5
\nRoom 5.17.007
\nT<\/strong> (514) 345-4931 ext. 7876<\/p>\n

Contact details (School of Rehabilitation)
\nT<\/strong> 514 343-6111 ext. 7494
\nnicolas.dumont.1@umontreal.ca<\/a><\/p>\n

Program<\/strong>
\n<\/strong>Physiotherapy<\/p>\n<\/div>\n\n

Education<\/h2>\n
    \n
  • B.Sc. Physiotherapy, University Laval (2005)<\/li>\n
  • M.Sc. Physiology-endocrinology, CHUQ research center, University Laval (2007)<\/li>\n
  • Ph.D. Physiology-endocrinology, CHUQ research center, University Laval (2013)<\/li>\n
  • Post-doctoral fellow in regenerative medicine, Ottawa Hospital Research Institute, University of Ottawa (2013-2016)<\/li>\n<\/ul>\n

    Current research projects<\/h2>\n
      \n
    • The role of acute and chronic inflammation on skeletal muscle regeneration<\/li>\n
    • The effect of pro-resolving mediators of inflammation for the treatment of muscle injuries and diseases<\/li>\n
    • Muscle stem cell dysfunction in muscle diseases<\/li>\n
    • Functional characterisation of novel rare myopathies<\/li>\n<\/ul>\n

      Selected publications<\/h2>\n
        \n
      • Feichtinger, R. G., Mucha, B. E., Hengel, H., Orfi, Z., Makowski, C., Dort, J., . . . Dumont, N. A.<\/strong> (2019). Biallelic variants in the transcription factor PAX7 are a new genetic cause of myopathy. Genetics in Medicine, 21<\/em>(11), 2521-2531. doi:10.1038\/s41436-019-0532-z<\/li>\n
      • Duchesne, E., Dufresne, S. S., & Dumont, N. A.<\/strong> (2017). Impact of Inflammation and Anti-inflammatory Modalities on Skeletal Muscle Healing: From Fundamental Research to the Clinic. Physical Therapy, 97<\/em>(8), 807-817. doi:10.1093\/ptj\/pzx056<\/li>\n
      • Dumont, N. A.<\/strong>, Wang, Y. X., von Maltzahn, J., Pasut, A., Bentzinger, C. F., Brun, C. E., & Rudnicki, M. A. (2015). Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division. Nature Medicine, 21<\/em>(12), 1455-1463. doi:10.1038\/nm.3990<\/li>\n
      • Dufresne, S. S., Dumont, N. A.<\/strong>, Boulanger-Piette, A., Fajardo, V. A., Gamu, D., Kake-Guena, S. A., . . . Frenette, J. (2016). Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles. American Journal of Physiology. Cell Physiology, 310<\/em>(8), C663-672. doi:10.1152\/ajpcell.00285.2015<\/li>\n
      • Dick, S. A., Chang, N. C., Dumont, N. A.<\/strong>, Bell, R. A., Putinski, C., Kawabe, Y., . . . Megeney, L. A. (2015). Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. Proceedings of the National Academy Sciences of the United States of America, 112<\/em>(38), E5246-5252. doi:10.1073\/pnas.1512869112<\/li>\n
      • Dumont, N. A.<\/strong>, Wang, Y. X., & Rudnicki, M. A. (2015). Intrinsic and extrinsic mechanisms regulating satellite cell function. Development, 142<\/em>(9), 1572-1581. doi:10.1242\/dev.114223<\/li>\n
      • Dufresne, S. S., Dumont, N. A.<\/strong>, Bouchard, P., Lavergne, E., Penninger, J. M., & Frenette, J. (2015). Osteoprotegerin protects against muscular dystrophy. American Journal of Pathology, 185<\/em>(4), 920-926. doi:10.1016\/j.ajpath.2015.01.006<\/li>\n
      • Price, F. D., von Maltzahn, J., Bentzinger, C. F., Dumont, N. A.<\/strong>, Yin, H., Chang, N. C., . . . Rudnicki, M. A. (2014). Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nature Medicine, 20<\/em>(10), 1174-1181. doi:10.1038\/nm.3655<\/li>\n
      • Dumont, N. A.<\/strong>, & Frenette, J. (2013). Macrophage colony-stimulating factor-induced macrophage differentiation promotes regrowth in atrophied skeletal muscles and C2C12 myotubes. American Journal of Pathology<\/em>, 182<\/em>(2), 505-515. doi:10.1016\/j.ajpath.2012.10.010<\/li>\n<\/ul>\n

        Research interests<\/h2>\n
          \n
        • Musculoskeletal regeneration<\/li>\n
        • Acute and chronic inflammation<\/li>\n
        • Atrophied muscle function<\/li>\n
        • Muscle dystrophies<\/li>\n
        • Tendinopathies<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

          Education B.Sc. Physiotherapy, University Laval (2005) M.Sc. Physiology-endocrinology, CHUQ research center, University Laval (2007) Ph.D. Physiology-endocrinology, CHUQ research center, University Laval (2013) Post-doctoral fellow in regenerative medicine, Ottawa Hospital Research […]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":13845,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-13858","page","type-page","status-publish","hentry"],"yoast_head":"\nNicolas Dumont, Ph.D. - \u00c9cole de r\u00e9adaptation - Universit\u00e9 de Montr\u00e9al<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/readaptation.umontreal.ca\/en\/research\/researchers\/nicolas-dumont-pt-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nicolas Dumont, Ph.D. - \u00c9cole de r\u00e9adaptation - Universit\u00e9 de Montr\u00e9al\" \/>\n<meta property=\"og:description\" content=\"Education B.Sc. 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